U.S. scientists have discovered a method that spurs damaged heart cells to regenerate and also improves heart function.
When human hearts are injured, as during heart attacks, healthy tissue normally can't re-grow. But Children's Hospital Boston scientists demonstrated in rats that a sponge-like patch, soaked in a compound called periostin and placed over the injury, can cause heart cells to begin dividing and making copies of themselves.
eriostin is a component of the material that surrounds cells and is derived from the skin around bone. Although the mature heart only has tiny amounts, it's abundant during fetal heart development and increased amounts are produced after skeletal-muscle injury.
The researchers, led by Dr. Bernhard Kuhn, discovered placing periostin near the site of a myocardial infarction can help heart tissue regenerate.
Kuhn, a pediatric cardiologist, envisions using a sustained-delivery periostin patch not only to treat adults with heart attack but also to encourage cardiomyocyte proliferation in children with congenital heart disease.
Kuhn, Dr. Mark Keating and colleagues at Massachusetts General Hospital and the Mount Sinai School of Medicine report the research in the July 15 online issue of the journal Nature Medicine.
美国科学家发明了一种方法，刺激受损的心肌细胞再生，同时提高心脏功能。
当人的心脏受损，如心脏病发作，健康组织通常不会再生。但是波士顿儿童医院的科学家发现，在老鼠心肌受损的地方放上吸收了化合物periostin的海绵状斑块，受损的细胞可以分裂和复制。
Periostin是一种从骨附近皮肤提取的物质，主要存在于细胞周围。这种物质，在胎心发育和骨骼肌受损的时候含量很高。
Bernhard Kuhn领导的研究者发现，在心肌梗死灶附近放置periostin可以促进心肌组织再生。
儿科心脏病专家Kuhn设想，使用一种持续性periostin递送系统，不仅治疗成人心脏病发作，而且治疗儿童先天性心脏病。
马萨诸塞州综合医院和Mount Sinai医学院的Kuhn，Mark Keating博士及其同事，将此研究发表在7月15号《自然》杂志医学版的网络版上。
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